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Glutathione – the master antioxidant

Glutathione conjugation is one of the 6 phase 2 detox pathways of the body, responsible for approximately 60% of toxin processing

Glutathione is a peptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue. In the body, glutathione’s action is 3 pronged: it acts as an antioxidant, a free radical scavenger and a detoxifying agent.


Geek corner

Alongside acetylation, glucuronidation, sulfation, amino acid conjugation and methylation, glutathione conjugation is one of the 6 phase 2 detox conjunction pathways of the body; it is responsible for approximately 60% of toxin processing in the body.

Detox Scope

Glutathione helps with general body detoxification, but is especially useful in detoxifying:

  • metals, alongside alpha lipoic acid
  • mold, alongside oregano oil
  • pesticides/herbicides, alongside activated charcoal

It is also an indispensable agent in both phases of liver detoxification.


Dosage and sources

As a supplement, it is best when glutathione is administered in its liposomal form (attached to tiny fat particles, called liposomes) in doses of 500mg once or twice daily, ideally sublingually. It works synergistically with other detox procedures, such as hot sauna sessions or more controversial coffee enemas, both of which up-regulate glutathione production.

However, glutathione is best obtained, when possible, through food intake. Given it is a tri-peptide, an adequate protein intake is the basic requirement to maintain sufficient glutathione levels.

Good food sources of glutathione are sulphur rich foods, such as pork loin, chicken liver, beef steak, whey protein, as well as asparagus, potatoes, avocado, zucchini, tomatoes, okra, spinach, parsley and cruciferous vegetables.


Interactions with other nutrients

A few other nutrients also help with internal glutathione production and maintenance:

  • resveratrol, an antioxidant which can cross the blood brain barrier and can, alongside alpha lipoic acid, recycle glutathione within the body
  • vitamin C
  • curcumin, found in turmeric
  • milk thistle, which inhibits depletion of liver glutathione
  • selenium, needed for the production of glutathione peroxidase, one of the enzymatic forms of glutathione

Beyond detox

Glutathione is also necessary for regulation of telomerase activity, an enzyme that extends the length of chromosomal telomeres, as well as for maintenance of the mitochondrial matrix, our cells’ energy producing factory.


Measuring glutathione levels

So how can you track your glutathione levels? Well, lab results looking at GGT and glutathione peroxidase are a good start. GGT is a liver enzyme used in glutathione transportation and biosynthesis, whereas levels of glutathione peroxidase are a good proxy for longevity in general. A more direct look at glutathione levels in various types of cells, such as monocytes, lymphocytes and natural killer cells is a more expensive, but also more relevant test.

And… action

And what can you do about glutathione? You can either build a strategy for continuous replenishment of glutathione precursors or ask us to help you in the process through the nutrigenomic counselling we offer, whichever seems easier to do. Our genetic and metabolic optimization approach is probably one of the most comprehensive out there.