X Files: Anti-aging Spermidine & Autophagy
Average daily nutritional intake of spermidine varies between 7 and 25 mg
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Biochemistry
The Logic of Fasting: Insulin
Fasting may be associated with a reduced risk of age-related diseases and a longer lifespan
What the Pomegranate?
Individuals with metabotype B may be at a higher risk of CVD compared to those with metabotype A
Insulin Sensitivity Management: Berberine
AMPK and its agonist, berberine, can combat some underlying events of neurodegeneration
Hmm.. Thor has an Upregulated mTOR
Curcumin, a compound found in turmeric, has anti-aging effects by the inhibition of mTORC1 activity
Mitochondria: from Energy to Brown Fat
Amino acids yield lower amounts of ATP than glucose as they enter the energy production cycle later in the process
Digestion: Omega, Gut, Fat & Bile
The presence of high levels of fat in the diet can inhibit the absorption of carbohydrates, while high levels of fiber (non-digestible carbs) can interfere with the absorption of fat
Nitrogen to Ammonia to Urea: Toxic Alert
Eating a low protein diet can help to reduce the amount of excess nitrogen in the body and minimize the burden on the urea cycle
Fasting – Recycle – Autophagy
There are two main pathways involved in nutrient availability that inhibit or suppress autophagy: cAMP-dependent protein kinase A (PKA) and mTOR (mechanistic target of rapamycin)
Methylation: Beyond Creatine & DNA
COMT is responsible for the methylation of catecholamines, such as dopamine, norepinephrine, and epinephrine