Phase 3 Detox: ABC Transporters
Our genetic and metabolic optimization approach: what is your starting level, a.k.a. your genetic make-up, and what is your ongoing metabolism, a.k.a. your epigenetic influences or how you express your genes
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Metabolism
Fasting – Recycle – Autophagy
There are two main pathways involved in nutrient availability that inhibit or suppress autophagy: cAMP-dependent protein kinase A (PKA) and mTOR (mechanistic target of rapamycin)
What do Aspirin, BPA & NSAIDs have in common? Glucuronidation!
Mycotoxins are substances made by fungi that are present in many foods, such as cereals, nuts, and spices
Sulfation: From Heavy Metal to DHEA-S
Taurine and garlic are believed to both be excellent dietary sources of required sulfur and induce some sulfotransferases, like SULT1E1
PON: Cholesterol Meets Detox
Pomegranate polyphenols can enhance PON2 expression, whereas consuming yerba mate can enhance all PON enzymes’ activity
Phase 1 Liver Detox: CYP P450 and Waste Management
Milk thistle contains silymarin, a compound that has been shown to have liver-protective effects
FOXO: the Insulin Controller
FOXO3 activation extends lifespan in animal models, and has been suggested to be a potential target for interventions to promote healthy aging in humans
Sirtuins and Healthy Aging
While SIRT7 has been implicated in the control of gene expression, SIRT6 has been implicated in the repair of DNA damage
Genetic and metabolic optimization 101
Tackling inflammation, antioxidants, detoxification pathways and improving metabolism are built on a strong dietary and lifestyle baseline