Fasting – Recycle – Autophagy
There are two main pathways involved in nutrient availability that inhibit or suppress autophagy: cAMP-dependent protein kinase A (PKA) and mTOR (mechanistic target of rapamycin)
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Biochemistry
Methylation: Beyond Creatine & DNA
COMT is responsible for the methylation of catecholamines, such as dopamine, norepinephrine, and epinephrine
Selenium & Glutathione Conjugation
GPXs are selenoproteins, for which the availability of selenium is of key importance
Cortisol & Drugs Genetics: Acetylation
By acetylation, hydralazines are turned into hydrazides, which can then be excreted easier
What do Aspirin, BPA & NSAIDs have in common? Glucuronidation!
Mycotoxins are substances made by fungi that are present in many foods, such as cereals, nuts, and spices
Sulfation: From Heavy Metal to DHEA-S
Taurine and garlic are believed to both be excellent dietary sources of required sulfur and induce some sulfotransferases, like SULT1E1
Phase 1 Liver Detox: CYP P450 and Waste Management
Milk thistle contains silymarin, a compound that has been shown to have liver-protective effects
Sirtuins and Healthy Aging
While SIRT7 has been implicated in the control of gene expression, SIRT6 has been implicated in the repair of DNA damage
Catalase: Glutathione’s Sancho Panza
One catalase enzyme can change 40 million molecules of hydrogen peroxide into water and oxygen per second
SuperOxide Dismutase: The AOX Hero
Cantaloupe juice concentrate and apple polyphenols have been shown to increase SOD levels in several human trials