NOX Enzyme: NADPH Steal and the Holmes Cycle
The NADPH steal results in less available NADPH to support Phase 1 Detox, produce Nitric Oxide and recycle critical antioxidants, such as Glutathione
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Inflammation
CBS News: Sulfites and Inflammation
SUOX is responsible for breaking down sulfites into sulfates, which are then eliminated from the body through urine
Iron to Heme to Hemoglobin Essentials
When oxygen is inhaled, it binds to the iron atom in the heme, allowing hemoglobin to transport it through the bloodstream to the tissues that need it
Oxalobacter: Gut’s Best Friend Forever
One of the key ways in which oxalates can contribute to inflammation in the body is through the activation of the NLRP-3 inflammasome
Wheat or WheatOut: IBS & Gluten Free
The two main types of IBD are Crohn’s disease and ulcerative colitis, both of which are thought to be caused by an abnormal immune response to the bacteria in the gut
Allergy Stories: Are you Anti Histamine?
Histamine causes a number of physiological changes in the body, such as an increase in heart rate, blood vessel dilation, and mucus production
Glutamate & Excitotoxicity
Curcumin lowers glutamate levels by preserving glutamate transporter GLT-1 expression and function, leading to an attenuation of excitotoxicity
Fenton: linking Iron and Inflammation
Hydrogen peroxide (H2O2) can be hijacked by the Fenton reaction to produce highly inflammatory hydroxyl radicals (OH-)
Inflammation: Nitric Oxide Synthase
Nitric oxide synthase (NOS) is an enzyme that helps the body manage inflammation by producing nitric oxide (NO)
Genetic and metabolic optimization 101
Tackling inflammation, antioxidants, detoxification pathways and improving metabolism are built on a strong dietary and lifestyle baseline