Phase 3 Detox: ABC Transporters
Our genetic and metabolic optimization approach: what is your starting level, a.k.a. your genetic make-up, and what is your ongoing metabolism, a.k.a. your epigenetic influences or how you express your genes
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Detox
Nitrogen to Ammonia to Urea: Toxic Alert
Eating a low protein diet can help to reduce the amount of excess nitrogen in the body and minimize the burden on the urea cycle
Fasting – Recycle – Autophagy
There are two main pathways involved in nutrient availability that inhibit or suppress autophagy: cAMP-dependent protein kinase A (PKA) and mTOR (mechanistic target of rapamycin)
Methylation: Beyond Creatine & DNA
COMT is responsible for the methylation of catecholamines, such as dopamine, norepinephrine, and epinephrine
Selenium & Glutathione Conjugation
GPXs are selenoproteins, for which the availability of selenium is of key importance
Cortisol & Drugs Genetics: Acetylation
By acetylation, hydralazines are turned into hydrazides, which can then be excreted easier
What do Aspirin, BPA & NSAIDs have in common? Glucuronidation!
Mycotoxins are substances made by fungi that are present in many foods, such as cereals, nuts, and spices
Sulfation: From Heavy Metal to DHEA-S
Taurine and garlic are believed to both be excellent dietary sources of required sulfur and induce some sulfotransferases, like SULT1E1
PON: Cholesterol Meets Detox
Pomegranate polyphenols can enhance PON2 expression, whereas consuming yerba mate can enhance all PON enzymes’ activity
Phase 1 Liver Detox: CYP P450 and Waste Management
Milk thistle contains silymarin, a compound that has been shown to have liver-protective effects