X Files: Anti-aging Spermidine & Autophagy
Average daily nutritional intake of spermidine varies between 7 and 25 mg
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Autophagy
The Logic of Fasting: Insulin
Fasting may be associated with a reduced risk of age-related diseases and a longer lifespan
Hmm.. Thor has an Upregulated mTOR
Curcumin, a compound found in turmeric, has anti-aging effects by the inhibition of mTORC1 activity
Fasting – Recycle – Autophagy
There are two main pathways involved in nutrient availability that inhibit or suppress autophagy: cAMP-dependent protein kinase A (PKA) and mTOR (mechanistic target of rapamycin)
FOXO: the Insulin Controller
FOXO3 activation extends lifespan in animal models, and has been suggested to be a potential target for interventions to promote healthy aging in humans