Methylation: Beyond Creatine & DNA
COMT is responsible for the methylation of catecholamines, such as dopamine, norepinephrine, and epinephrine
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Nutrigenomics
Selenium & Glutathione Conjugation
GPXs are selenoproteins, for which the availability of selenium is of key importance
Cortisol & Drugs Genetics: Acetylation
By acetylation, hydralazines are turned into hydrazides, which can then be excreted easier
What do Aspirin, BPA & NSAIDs have in common? Glucuronidation!
Mycotoxins are substances made by fungi that are present in many foods, such as cereals, nuts, and spices
Sulfation: From Heavy Metal to DHEA-S
Taurine and garlic are believed to both be excellent dietary sources of required sulfur and induce some sulfotransferases, like SULT1E1
PON: Cholesterol Meets Detox
Pomegranate polyphenols can enhance PON2 expression, whereas consuming yerba mate can enhance all PON enzymes’ activity
Phase 1 Liver Detox: CYP P450 and Waste Management
Milk thistle contains silymarin, a compound that has been shown to have liver-protective effects
FOXO: the Insulin Controller
FOXO3 activation extends lifespan in animal models, and has been suggested to be a potential target for interventions to promote healthy aging in humans
Sirtuins and Healthy Aging
While SIRT7 has been implicated in the control of gene expression, SIRT6 has been implicated in the repair of DNA damage
Catalase: Glutathione’s Sancho Panza
One catalase enzyme can change 40 million molecules of hydrogen peroxide into water and oxygen per second