Fasting – Recycle – Autophagy
There are two main pathways involved in nutrient availability that inhibit or suppress autophagy: cAMP-dependent protein kinase A (PKA) and mTOR (mechanistic target of rapamycin)
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Gabi
Passionate about fitness and exercise and how these contribute to sustained health. Biotech engineering background
Cortisol & Drugs Genetics: Acetylation
By acetylation, hydralazines are turned into hydrazides, which can then be excreted easier
PON: Cholesterol Meets Detox
Pomegranate polyphenols can enhance PON2 expression, whereas consuming yerba mate can enhance all PON enzymes’ activity
Sirtuins and Healthy Aging
While SIRT7 has been implicated in the control of gene expression, SIRT6 has been implicated in the repair of DNA damage
NAD(H) & NADP(H), Your AntiOx Best Friends
Sirtuins have been shown to have a variety of effects on aging and longevity and NAD+ is involved in the regulation of gene expression through the action of these enzymes
NOX Enzyme: NADPH Steal and the Holmes Cycle
The NADPH steal results in less available NADPH to support Phase 1 Detox, produce Nitric Oxide and recycle critical antioxidants, such as Glutathione
Oxalobacter: Gut’s Best Friend Forever
One of the key ways in which oxalates can contribute to inflammation in the body is through the activation of the NLRP-3 inflammasome
Glutamate & Excitotoxicity
Curcumin lowers glutamate levels by preserving glutamate transporter GLT-1 expression and function, leading to an attenuation of excitotoxicity
Cold Thermogenesis & Brown Adipose Tissue
Cold exposure can improve cardiovascular health by increasing the production of “good” cholesterol (HDL) and decreasing the production of “bad” cholesterol (LDL)
Energy Expenditure: NEAT
Non-exercise activity thermogenesis (NEAT) refers to the energy your body uses for activities other than planned exercise